Johns Hopkins University - Recruitment Strategies

1. Viral and Immune Studies in the Lung and Blood of HIV-infected Individuals: Eligible participants for this protocol will be recruited from among the Study of HIV Infection in the Etiology of Lung Disease (SHIELD) study participants that have enrolled and undergone HRCT and PFTs as party of the SHIELD COPD Protocol. Over the course of this study we anticipate enrolling approximately 70-100 participants over 3-5 years, with our goal to perform approximately 20-30 bronchoscopies per year.

2. Study of Pulmonary Inflammation in HIV Infection: The participants will be recruited from the Johns Hopkins Hospital HIV Clinic Cohort (JHHCC - Moore clinic). The JHHCC is the clinic based arm of the SHIELD cohort. The HIV primary care clinical practice includes a multidisciplinary team of 31 primary care providers delivering integrated care and support services in one location. In 1990, the JHHCC was established to provide comprehensive longitudinal data on patients enrolled in the HIV clinic to assess the effect of newly developed antiretroviral therapy on the natural history of HIV disease. Since 1996, greater than 4,800 patients have been enrolled. The median age of the cohort is 41 years with 31% female and 80% African American. Ever smoking was reported by 72%, while 69% report current smoking. While the entire cohort is HIV-infected, 71% were on ART. The HIV clinic regularly initiates newly diagnosed or disease progressing HIV-infected individuals, providing an enriched recruitment pool to accomplish this proposal.