Aging with HIV

  • Cancer
  • MI
  • ESLD
  • ESRD
  • Comorbidities
  • Multi-morbidity

Effective antiretroviral therapy has led to improved survival for people with HIV, with the life expectancy of treated patients in the United States and Canada now approaching that of the general population. With this normalization of life expectancy has come an increase in occurrences of age-related comorbidities, including cardiovascular disease, cancer, liver disease, and renal disease, among people with HIV. The North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) receives federal funding, as part of the American Recovery and Reinvestment Act of 2009, to validate occurrences of myocardial infarctions, cancers, end-stage renal disease, and end-stage liver disease among adults with HIV in NA-ACCORD contributing cohorts from 2000 to 2010. Since 2010, the NA-ACCORD has continued to validate myocardial infarctions, cancers, and end-stage liver disease among participants.

To learn more about the validation process, please see the following publications:

Myocardial infarction (the NA-ACCORD used the same validation process as the Center for AIDS Research Network of Integrated Clinical Systems (CNICS): Crane HM, et al. Lessons learned from the design and implementation of myocardial infarction adjudication tailored for HIV clinical cohorts. American Journal of Epidemiology 2014;179(98):996-1005.

Cancer: Silverberg MJ, et al. Cumulative incidence of cancer among HIV-infected individuals in North America. Annals of Internal Medicine 2015;163(7):507-18.

End-stage liver disease and end-stage renal disease: Kitahata M et al. Ascertainment and verification of end-stage renal and liver disease in the North American AIDS Cohort Collaboration on Research and Design. AIDS Research and Therapy 2015; 2015:923194.

Number of participating cohorts and calendar years of validation, by condition.


  • Cumulative incidence

  • Standardized incidence ratio

  • Median age at diagnosis

  • Mortality rates


  • Incidence

  • Risk factors


  • Incidence

  • HBV-active ART


  • Incidence

  • Risk factors

  • Cumulative incidence by viral load and CD4 count

  • Cumulative incidence by eGFR and HIV status


  • Incidence of HTN, DM, CKD

  • Cumulative incidence of HTN, DM, CKD


  • Prevalence by calendar year

  • Prevalence by age

  • Co-occurrence of most common conditions